Price and configuration of chromatograph for detecting ethylene oxide (EO) residues
—AHS-20A plus fully automated headspace sampler + GC-9860 gas chromatograph
This method, referencing GB/T16886.7-2001, is applicable to the sterilization of medical supplies, particularly gauze and plastic medical supplies, and especially medical devices. Ethylene oxide sterilization is increasingly widely used. The quality of ethylene oxide significantly affects the sterilization effect, and residual ethylene oxide in sterilized items poses a health hazard to patients and medical personnel. For medical devices used in extracorporeal circulation, ethylene oxide is more toxic to humans and animals than carbon tetrachloride and chloroform, and similar to ammonia. Ethylene oxide is corrosive to the eyes and respiratory tract, causing vomiting, nausea, diarrhea, headache, central nervous system depression, difficulty breathing, pulmonary edema, and may also cause liver and kidney damage and hemolysis. Excessive skin contact with liquid or solution ethylene oxide can cause a burning sensation, blisters, and dermatitis; systemic reactions may occur if absorbed through the skin.
AHS-20A plus fully automated headspace sampler + GC-9860 gas chromatograph: methodology
This method employs the principle of headspace gas chromatography (AHS-20A plus fully automated headspace sampler + GC-9860 gas chromatograph). It's a chromatographic technique that adds a headspace sampler before the gas chromatograph's injection port, combining the headspace sampler with the gas chromatograph. It utilizes the heated equilibrium of the sample (gas-liquid and gas-solid) and then introduces the volatile gas fraction into the gas chromatograph. It is specifically designed for analyzing trace volatile components, such as methanol, ethanol, and many other volatile organic solvents; floral fragrances and perfumes from different seasons; traditional Chinese medicines containing volatile components; and vegetables and seasonings with distinctive aromas. For the detection of residual solvents in medical devices, a solution is to use a headspace sampler for injection, separate the sample using a capillary column, and detect the residual solvent content using a flame ionization detector. This method is simple to operate, effective, and efficient, making it an essential detection solution for the sterilization quality control of medical devices.
Economical and efficient instrument configuration (can be operated unattended, improves work efficiency, saves labor costs, highly automated, and provides accurate measurements).
1. GC-9860 gas chromatograph, FID flame ionization detector; 1 unit
2. BF-2002 chromatographic data processing; 1 set
3. AHS-20A plus fully automated headspace sampler; 1 unit
4. Nitrogen, hydrogen, and air generators; 1 unit each
5. Column for ethylene oxide analysis; 1 column
6. 20ml headspace bottles; 100 bottles/box
7. Aluminum cap + headspace pad; 100 pieces/pack
8. Headspace bottle capper; 1 piece
9. Headspace bottle opener; 1 piece
Instrument Introduction :
The AHS-20A Plus fully automated headspace sampler is a newly launched, affordable, high-performance, and widely applicable sample pretreatment device for gas chromatographs by Beijing Beifen Sanpu Instrument Co., Ltd. It can rapidly and accurately extract volatile compounds from any matrix and transfer them intact to the gas chromatograph. The instrument features a 7.0-inch graphic dot-matrix LCD screen with a user-friendly, clear, and concise interface. The animation display and settings, based on the injection principle, allow for easy and quick operation without requiring much effort from the user.
Main technical parameters:
●Sample heating range: 40℃—220℃, temperature control accuracy 1℃
(Up to 300℃ can be configured according to customer requirements)
● Heating range of the injection valve: 40℃—220℃, temperature control accuracy 1℃
(Up to 300℃ can be configured according to customer requirements)
●Sample transfer tube heating range: 40℃—220℃, temperature control accuracy 1℃
(Up to 300℃ can be configured according to customer requirements)
●Temperature accuracy: 0.5%
●Temperature stability: <±0.5℃
●Pressure time: 0-999 seconds
●Sampling time: 0-30 min
●Injection time: 0-999 seconds
● Cleaning time: 0-30 min
*●Time interval setting: minimum 1ms (0.001s)
●Pressure: 0~0.25Mpa (continuously adjustable)
●Quantitative tube volume: 1ml (Other specifications can be customized, such as 0.5ml, 2ml, 5ml, etc.)
● Headspace vial specifications: 10ml or 20ml (Other specifications can be customized, such as 50ml, 100ml, etc.)
●Sample workstations: 20
●Can heat samples simultaneously: 1 position
●RSD: <1.0% (100ppm ethanol aqueous solution)
● Backflush cleaning flow rate: 0～100ml/min (continuously adjustable)
●Synchronous startup of the chromatography data processing workstation, GC, or external event to simultaneously start this device.
● Computer USB communication interface; all parameters can be set via computer or panel, offering convenience and speed.
Instrument features:
*▲ A 7-inch LCD screen with full Chinese language display, simple operation, and one-button start. Automatic heating balancing, pressurization, sampling, injection, analysis, and post-analysis rinsing functions, as well as sample vial replacement, achieve fully automated workflow.
▲ It can pre-set 20 samples, greatly improving time utilization. No manual intervention is required, improving the reliability and consistency of the analysis.
▲It has complete parameter settings, real-time working status, running time, year, month, day, etc.
*▲Comprehensive power-on self-test function, automatic alarm for sample tray positioning, component failure, wiring failure, etc.
*▲Multiple injection modes: single vial multiple injections, single vial single injection, multiple vials single injection.
*▲ It features multiple fault diagnosis and handling modes, automatically determining the sample vial position and avoiding unfilled areas. In case of positional faults, it prevents vial collisions. In case of abnormal mechanical movement, it automatically stops and issues a warning, effectively ensuring reliable high-precision movement and preventing damage.
▲All sample transfer lines and quantitative loops use imported high-inert deactivation lines, which are free of residue and cross-contamination, ensuring the repeatability and accuracy of sample injection.
*▲The combination of the six-way valve and the quantitative loop minimizes the dead volume and ensures injection accuracy.
▲The connection point between the six-way valve and the transmission pipeline is located inside the heating and insulation box, eliminating cold spots during transmission and ensuring the integrity of the sample.
▲ Employing the classic positive pressure sampling method, it can measure liquid or solid samples with high detection sensitivity. At atmospheric pressure injection prevents baseline drift.
*▲All movements are driven by motors, requiring no external driving gas, making it safe and convenient to use.
▲ It has strong compatibility and can be connected to various gas chromatographs at home and abroad. It can start the chromatograph and workstation simultaneously and work in conjunction with the chromatograph.
▲Six-way valves with different operating temperatures and imported inert injection needles can be selected according to customer needs.
▲Electronic flow control (EPC) is used to improve instrument reliability (optional).
Appendix: Headspace Sampler Implementation Standards
1. Public Security Industry Standard of the People's Republic of China GA/T842-2009
2. GB3838-2002 Drinking Water and Drinking Water Sources, Industrial Wastewater, Drinking Natural Mineral Water (GB8537-2008), Hygienic Standards for Drinking Water (GB 5749-2006), and 13 national standards for the inspection of drinking water hygiene.
3. GB/T 17130-1997 Determination of Volatile Halogenated Hydrocarbons in Water - Headspace Gas Chromatography
Industry Standards - Environmental Protection: Standards Regarding Headspace Gas Chromatography and Gas Chromatography-Mass Spectrometry
4. HJ 736-2015 Determination of volatile halogenated hydrocarbons in soil and sediments by headspace/gas chromatography-mass spectrometry
5. HJ 642-2013 Soil and Sediments. Determination of Volatile Organic Compounds. Headspace/Gas Chromatography-Mass Spectrometry
6. HJ 643-2013 Solid waste. Determination of volatile organic compounds. Headspace/gas chromatography-mass spectrometry.
Industry Standards - Tobacco, Standards Regarding Headspace Gas Chromatography and Gas Chromatography-Mass Spectrometry
7. YC/T 207-2014 Determination of Solvent Residues in Tobacco Paper by Headspace-Gas Chromatography/Mass Spectrometry
Industry Standards - Commodity Inspection: Standards Regarding Headspace Gas Chromatography and Gas Chromatography-Mass Spectrometry
8. SN/T 4068-2014 Determination of residual solvents in the coating of regenerated cellulose film materials for food contact – Headspace-gas chromatography/mass spectrometry
9. SN/T 3616-2013 Determination of Volatile Organic Compounds in Wood Materials by Headspace Gas Chromatography-Mass Spectrometry
10. TCVN 7873-2008 Determination of benzene content in water by headspace and purge-trap gas chromatography/mass spectrometry
Standards of the Ministry of Environmental Protection of the People's Republic of China on Headspace Gas Chromatography and Gas Chromatography-Mass Spectrometry
11. HJ 714-2014 Determination of Volatile Halogenated Hydrocarbons in Solid Waste by Headspace/Gas Chromatography-Mass Spectrometry
12. HJ 810-2016 Determination of Volatile Organic Compounds in Water by Headspace/Gas Chromatography-Mass Spectrometry
13. HJ 643—2013 Determination of Volatile Organic Compounds in Solid Waste by Headspace/Gas Chromatography-Mass Spectrometry
HJ 642—2013 Determination of Volatile Organic Compounds in Soil and Sediments by Headspace/Gas Chromatography-Mass Spectrometry
14. Headspace gas chromatography, Part III, Chinese Pharmacopoeia 2015 Edition
15. Chinese Pharmacopoeia 2015 Edition, Part IV, Pharmaceutical Excipients, p. 522, Top Gas Chromatography
16. HJ 895-2017 Determination of Methanol and Acetone in Water by Headspace/Gas Chromatography
17. HJ 741-2015 Determination of Volatile Organic Compounds in Soil and Sediments by Headspace Gas Chromatography, etc. Beijing Beifen Sanpu Instrument Co., Ltd. is a professional analytical instrument manufacturer integrating R&D, production, sales, and service. Main products include: gas chromatographs, headspace samplers, thermal desorption instruments, desorption tube aging instruments, digital soap film flow meters, hydrogen generators, air generators, nitrogen generators, etc. The company has a team of engineers with extensive experience in chromatograph development, analytical applications, and maintenance, possessing strong technical capabilities in the maintenance, repair, and debugging of chromatographic instruments. In recent years, we have provided a large number of advanced analytical instruments and equipment, as well as complete system solutions, to well-known domestic universities, research institutions, manufacturing enterprises, and testing and inspection organizations. It is precisely because of our high-quality products, professional applications, and comprehensive pre-sales and after-sales service that we have won the support and trust of our users and enjoy a good reputation.
Technical Department of Beijing Beifen Sanpu Instrument Co., Ltd.
